The Portuguese manager was appointed by Spurs in November 2019, replacing Mauricio Pochettino, and had signed a deal until the end of the 2022-23 season.
The 58-year-old leaves the North London club seventh in the Premier League table, five points off the UEFA Champions League places.
Mourinho’s last game in charge was Friday’s 2-2 draw away in the league at Everton.
“José is a true professional who showed enormous resilience during the pandemic.
“On a personal level, I have enjoyed working with him and regret that things have not worked out as we both had envisaged.
“He will always be welcome here and we should like to thank him and his coaching staff for their contribution,” Levy added.
Mourinho’s representatives were not immediately available for comment when contacted by CNN.
The club added that former player Ryan Mason will take First Team training on Monday.
Tottenham face Manchester City in the Carabao Cup Final at Wembley Stadium on Sunday with the club bidding to win its first piece of silverware in 13 years.
More to follow